Praxis of ORL: Rekürren tonsillit ve hipertrofik tonsilli hastalarda D vitamini düzeylerinin enflamasyonla ilişkisi | Relationship between vitamin D levels and inflammation in patients with recurrent tonsillitis and hypertrophic tonsil
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Praxis of ORL. Year: 2024  Volume: 12  Issue: 1  30-36
doi: 10.5606/kbbu.2024.34635

Rekürren tonsillit ve hipertrofik tonsilli hastalarda D vitamini düzeylerinin enflamasyonla ilişkisi

İhsan Delioğlu1, Emrah Sapmaz2, Zeliha Cansel Özmen3
1Elbistan Devlet Hastanesi Kulak Burun Boğaz Kliniği, Kahramanmaraş, Türkiye
2Tokat Gaziosmanpaşa Üniversitesi Tıp Fakültesi Kulak Burun Boğaz Anabilim Dalı, Tokat, Türkiye
3Tokat Gaziosmanpaşa Üniversitesi Tıp Fakültesi Biyokimya Anabilim Dalı, Tokat, Türkiye

AMAÇ: Bu çalışmada rekürren tonsillit ve hipertrofik tonsilli hastalarda D vitamini düzeylerinin enflamasyonla ilişkisi araştırıldı.
YÖNTEMLER: Bu prospektif çalışmaya Ekim 2016 - Şubat 2018 tarihleri arasında başvuran ve rekürren tonsillit (n=30) veya tonsil hipertrofisi (n=30) nedeniyle ameliyat endikasyonu konan 60 hasta dahil edildi. Kliniğimize başvuran 30 sağlıklı gönüllü kontrol grubu olarak çalışmaya dahil edildi. D vitamini, interlökin (IL)-17, IL-18, immümoglobulin (Ig)A ve IgG değerleri elde edilerek gruplar arasındaki farklar araştırıldı.
BULGULAR: Rekürren tonsillit grubunda IL-17 düzeyleri kontrol grubuna kıyasla anlamlı düzeyde yüksek idi (p=0.012). Rekürren tonsillit grubunda hipertrofik tonsil grubuna kıyasla doku IgA düzeyleri anlamlı düzeyde yüksek bulundu (p=0.042). Rekürren tonsillit grubunda 17 (%56.7) hastada ve tonsiller hipertrofi grubunda 12 (%40) hastada D vitamin düzeyi yetersizlik sınırı olan 20 ng/mL’nin altında saptandı.
SONUÇ: Bu çalışmada rekürren tonsillitli ve hipertrofik tonsilli hastalarla sağlıklı kontroller arasında vitamin D, IL-18, IgG ve IgA düzeyleri açısından anlamlı farklılık yoktu. Rekürren tonsillit ve hipertofik tonsil grubundaki hastaların IL-17 düzeyleri kontrol grubuna göre yüksek idi.

Anahtar Kelimeler: Rekürren tonsillit, tonsil hipertrofisi, D vitamini.


Relationship between vitamin D levels and inflammation in patients with recurrent tonsillitis and hypertrophic tonsil

İhsan Delioğlu1, Emrah Sapmaz2, Zeliha Cansel Özmen3
1Department of Otorhinolaryngology, Elbistan State Hospital, Kahramanmaraş, Türkiye
2Department of Otorhinolaryngology, Tokat Gaziosmanpaşa University Faculty of Medicine, Tokat, Türkiye
3Department of Biochemistry, Tokat Gaziosmanpaşa University Faculty of Medicine, Tokat, Türkiye

OBJECTIVE: This study aimed to study the relationship between vitamin D levels and inflammation in patients with recurrent tonsillitis and hypertrophic tonsils.
METHODS: Sixty patients who were admitted between October 2016 and February 2018 and who either had indications for operation due to recurrent tonsillitis (n=30) or tonsillar hypertrophy (n=30) were included in the prospective study. Thirty healthy volunteers who applied to our clinic were included in the study as the control group. Vitamin D, interleukin (IL)-17, IL-18, immunoglobulin (Ig)A, and IgG were obtained, and the differences between the groups were investigated.
RESULTS: The IL-17 levels in the recurrent tonsillitis group were found to be significantly higher than in the control group (p=0.012). The tissue IgA levels were significantly higher in the recurrent tonsillitis group compared to the hypertrophic tonsil group (p=0.042). In 17 (56.7%) patients in the recurrent tonsillitis group and 12 (40%) patients in the tonsillar hypertrophy group, vitamin D levels were found to be under 20 ng/mL, which is the level of insufficiency.
CONCLUSION: In this study, there was no significant difference between recurrent tonsillitis patients, hypertrophic tonsil patients, and healthy controls in terms of vitamin D, IL-18, IgG, and IgA levels. The IL-17 levels were higher in patients with recurrent tonsillitis and tonsillar hypertrophy patients compared to the control group.

Key words: Recurrent tonsillitis, tonsil hypertrophy, vitamin D.


İhsan Delioğlu, Emrah Sapmaz, Zeliha Cansel Özmen. Relationship between vitamin D levels and inflammation in patients with recurrent tonsillitis and hypertrophic tonsil. Praxis of ORL. 2024; 12(1): 30-36

Corresponding Author: Emrah Sapmaz, Türkiye: [email protected]


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